Best 60 How To Find Alternative Transcription Start Sites

How To Find Alternative Transcription Start Sites How To Find Alternative Transcription Start Sites

How To Find Alternative Transcription Start Sites

How to identify transcription start sites and alternative first exons?

Conventionally, identification of transcription start sites and alternative first exons on a genomic scale requires specialized experimental methods, such as CAGE and 5′-RACE, that capture the true 5′ ends of polymerase II transcripts ( 12, 13 ).

What are alternative transcription start sites (TSSs)?

( A) Alternative transcription start sites (TSSs) can appear in two forms: alternative first exons (AFEs) and alternative tandem TSSs.

Is Alternative transcriptional initiation adaptive?

PLoS Biology, 17(3), e3000197. Alternative transcriptional initiation (ATI) refers to the frequent observation that one gene has multiple transcription start sites (TSSs). Although this phenomenon is thought to be adaptive, the specific advantage is rarely known.

How do you determine the transcription start site of a gene?

Transcription start site (TSS) determination is very important for understanding gene structure and gene regulation. Presently TSS is determined by primer extension method, S1 nuclease mapping and RACE (RAPID AMPLIFICATION OF cDNA ENDS) techniques, but among these RACE is the most common method used to determine TSS..

How To Find Alternative Transcription Start Sites

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